Mounjaro Injections: Weight Loss – The Health Suite Leicester
Now available at The Health Suite, Leicester
When it comes to the world of weight management, a new age is unfolding, one where weight loss medication is finally catching up with the complexity of human metabolism.
If you’ve been struggling with your weight or managing insulin resistance, you’re not alone, and you’re certainly not lacking willpower. You might have noticed a frustrating pattern of losing and regaining the same 10 pounds over and over again.
Despite doing “everything right,” the scale doesn’t budge, or it does, only to rebound soon after. It’s a clear sign that the old model of calories in, calories out doesn’t fully explain what’s going on beneath the surface.
The truth is, our bodies are wired to hold on to weight, especially when hormones, blood sugar, and metabolism aren’t working in sync.
Your Body’s Set Weight Point
According to the set point theory, your body may be actively resisting fat loss to protect its perceived “set point”, which is a weight range it has learned to defend over time. This set point is often shaped by genetics, long-term dietary patterns, stress levels, and hormonal signals.
This means that when you try to lose weight, your body may not see it as progress.
In fact, it often interprets it as a potential threat to survival. In response, it activates powerful biological defenses: slowing down your metabolism, increasing hunger hormones like ghrelin, and suppressing fullness signals such as leptin, all in an effort to hold on to energy and restore lost weight.
This is why, after weeks of careful dieting, you might find yourself suddenly ravenous, exhausted, and regaining the weight you worked so hard to lose. It’s not necessarily about willpower, it’s about survival. Your physiology is working to keep you stable, even if that “stable” weight is far higher than what feels healthy or comfortable to you.
Enter Mounjaro…
Medications like Mounjaro injections are designed to help shift that internal balance. By mimicking key gut hormones involved in appetite regulation and insulin sensitivity, they can help “reset” those deeply rooted metabolic responses, so you’re not constantly fighting against your own biology.
Click here to learn more about the Weight loss injections and book appointments at The Health Suite Leicester.
It’s a revolutionary treatment that’s quickly earning global recognition not just for its powerful weight loss effects, but for how it redefines the very approach to obesity, insulin resistance, and metabolic health.
At The Health Suite in Leicester, we believe in weight loss solutions that are rooted in evidence and tailored to real life. Mounjaro weight loss injections represent a new kind of approach – one that works with your body’s natural systems to gently reduce appetite, stabilise blood sugar, and support long-term fat loss.
Click here to learn more about the Weight loss injections and book appointments at The Health Suite Leicester.
Mounjaro and Ozempic: Where Did They Come From?
You’ve probably heard about it all over the internet, maybe even seen dramatic success stories on TikTok or Instagram. But beyond the buzz, there’s real clinical science driving the excitement…
While there is a lot of fear mongering surrounding these weight loss medicines, what many people don’t realise is that weight loss injections like Mounjaro and its cousin, Ozempic, aren’t actually new in the true sense of the word.
Ozempic (semaglutide) was approved in 2017, and Mounjaro (tirzepatide) followed in 2022, but their development was built on over two decades of research into incretin hormones, particularly GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).
These gut-derived hormones were first identified in the 1980s and 90s as key players in regulating blood sugar and appetite. Since then, scientists have been exploring how they influence metabolism, hunger, and insulin secretion, paving the way for the GLP-1 receptor agonists we see today.
Now, with mounting data and global interest, doctors are tapping into that broader potential. Studies show that these therapies are no longer seen solely as diabetes drugs, they’re now recognised as powerful tools for weight management and obesity treatment.
Today, both Ozempic and Mounjaro are at the centre of a major shift in how we approach obesity, reflecting a deeper understanding of how the body controls weight – not as a personal failing, but as a treatable, medical condition.
Mounjaro, in particular, represents next-generation therapy. It targets not just one but two hormones – GLP1 and GIP – offering a dual mechanism that may help patients achieve even greater and more sustainable results.
In short: these weight loss treatments have been around longer than TikTok trends and headline buzz. Their rise isn’t just hype, it’s rooted in years of rigorous science, and they’re now changing the way we think about weight, healthy lifestyles, and what’s truly possible in the world of weight loss.
Click here to learn more about the Weight loss injections and book appointments at The Health Suite Leicester.
Benefits of Mounjaro (Tirzepatide)
- Dual Hormone Action: Mimics both GLP-1 and GIP, two key gut hormones involved in regulating appetite and blood sugar, making it more effective than GLP-1 medications alone.
- Appetite Suppression: Reduces hunger and cravings by targeting brain pathways involved in satiety, helping users feel full with smaller portions.
- Slows Gastric Emptying: Keeps food in the stomach longer, keeps you feeling fuller for longer, and reduces the urge to snack between meals.
- Significant Weight Loss: Clinical trials (e.g., SURMOUNT) show average weight loss of 15–22.5% of body weight, rivalling some bariatric procedures.
- Improves Insulin Sensitivity: Supports better blood sugar control, especially helpful for those with prediabetes, insulin resistance, or type 2 diabetes.
- Cardiometabolic Support: Helps lower blood pressure, reduce inflammation, and improve markers of cardiovascular health.
- Non-Invasive: Offers substantial results similar to bariatric surgery without having to go under the knife, making it a lower-risk alternative for individuals with obesity or overweight-related medical conditions.
- Once-Weekly Dosing: Convenient injection schedule which is easy to integrate into daily life.
The Measurable Impact of Mounjaro
Tirzepatide, the active ingredient in Mounjaro, is part of a class of medications that do more than just manage symptoms, they actually target the underlying hormonal pathways that influence hunger, fullness, and metabolic function.
Taken once weekly as a subcutaneous injection, Mounjaro is uniquely engineered to mimic not one but two key gut-derived hormones: GLP1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). Together, these hormones send powerful signals to the brain and digestive system that promote a sense of fullness, slow down digestion, and help regulate blood sugar.
Large-scale clinical trials, including the landmark SURMOUNT studies, have demonstrated that Mounjaro (tirzepatide) can lead to an average body weight reduction of 15% to over 20%, depending on the dose and duration of treatment. These outcomes are among the most significant ever observed in a medical weight management therapy, comparable to – and in some cases exceeding – the results of certain bariatric surgeries, but without the need for invasive procedures.
When combined with a balanced diet and consistent physical activity, Mounjaro’s impact becomes even more pronounced. In one trial, participants on the highest maintenance dose (15 mg) lost up to 22.5% of their initial body weight over a 72-week period, a result that truly highlights its potential as a powerful, biology-based tool for long-term weight loss and metabolic health.
Click here to learn more about the Weight loss injections and book appointments at The Health Suite Leicester.
Any Potential Mounjaro Side Effects?
As with any medication, Mounjaro isn’t without potential side effects. The most commonly reported include mild to moderate gastrointestinal symptoms such as nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, particularly when first starting or increasing the dose.
That said, these side effects typically lessen over time as the body adapts to the medication. While rare, more serious complications, such as pancreatitis or gallbladder issues, can occur – which is why careful monitoring and ongoing medical supervision are essential.
At The Health Suite in Leicester, our healthcare professionals provide the expert oversight and personalised care needed to ensure your treatment is both safe and effective from day one.
If you’re ready to take a science-backed, medically guided approach to weight loss – you’ve come to the right place.
Here at The Health Suite Leicester, we specialise in personalised treatment plans using advanced therapies like Mounjaro. Whether you’re just starting your journey or looking for support that finally works with your body.
Click here to learn more about the Weight loss injections and book appointments at The Health Suite Leicester.
Mounjaro operates by activating the GIP and GLP-1 pathways, crucial for regulating blood sugar levels after meals. By enhancing the natural incretin effect, it aids in insulin release when blood sugar is high and assists the body in removing excess sugar. This mechanism not only helps manage type 2 diabetes but also contributes to weight loss by reducing appetite and slowing stomach emptying.
– Individuals with a history of pancreatitis should consult their doctor, as it is not clear if Mounjaro is suitable for them.
– Mounjaro is not recommended for people with type 1 diabetes.
– Its safety and effectiveness in children under 18 years of age have not been established.
Both contain tirzepatide and work identically. Zepbound is the name used in the US for this medication, while Mounjaro is the name it’s licensed under in the UK.
Mounjaro is administered via a subcutaneous injection once a week. Patients are advised to follow a gradual dosage increase schedule to allow the body to adapt, starting with a 2.5 mg dose and potentially moving up to 5mg, 10mg, or 15mg as directed by their healthcare provider.
Common side effects include gastrointestinal issues like nausea, vomiting, diarrhea, and constipation, as well as fatigue and lightheadedness. It’s important to read the Patient Information Leaflet for a comprehensive list of side effects and advice on managing them.
Apart from Mounjaro, there are other weight loss treatments available, such as Wegovy, Saxenda, Orlistat, and Xenical. Lifestyle changes, including diet and exercise, play a critical role in weight management and are highly recommended in conjunction with any medication.
To manage side effects, staying hydrated, eating smaller, more frequent meals, and engaging in regular physical activity can be beneficial. For specific symptoms like constipation, increasing fiber intake is advised. Always consult a healthcare professional for personalized advice.
Switching involves a one-month washout period to allow the first drug to leave your system. Consultation with a healthcare provider is essential to assess suitability and ensure a safe transition.
References:
- Wilding, J.P.H., et al. (2021) Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/NEJMoa2032183 – Demonstrated significant weight loss in patients taking semaglutide (Ozempic/Wegovy), with average losses up to ~15%.
- Jastreboff, A.M., et al. (2022) Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038 – Key SURMOUNT-1 trial data showing up to 22.5% average weight loss with Mounjaro (tirzepatide) at 15mg over 72 weeks.
- Killion, E.A., Wang, J., Yie, J. et al. (2020) Tirzepatide, a dual GIP and GLP-1 receptor agonist, improves insulin sensitivity and energy expenditure in obese mice. Diabetes, 69(Supplement_1). – Preclinical mechanistic insights into how tirzepatide regulates appetite and metabolism.
- Holst, J.J. (2007) The physiology of glucagon-like peptide 1.
Physiological Reviews, 87(4), 1409–1439. https://doi.org/10.1152/physrev.00034.2006 – Overview of GLP-1 biology, satiety signaling, and impact on weight regulation. - Baggio, L.L. & Drucker, D.J. (2007) Biology of incretins: GLP-1 and GIP.
Gastroenterology, 132(6), 2131–2157. https://doi.org/10.1053/j.gastro.2007.03.054 – Describes the roles of GIP and GLP-1 in metabolic control and appetite regulation. - Sumithran, P., et al. (2011) Long-term persistence of hormonal adaptations to weight loss. New England Journal of Medicine, 365(17), 1597–1604.
https://doi.org/10.1056/NEJMoa1105816 – Discusses how the body’s hormonal responses resist weight loss, including ghrelin and leptin shifts. - Ravussin, E. & Ryan, D.H. (2019) Three decades of progress in understanding the biology of obesity.
Nature Metabolism, 1(1), 12–13. https://doi.org/10.1038/s42255-018-0002-4 – A review of biological complexity in obesity beyond calorie balance. - Mechanick, J.I., et al. (2013) Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient. Obesity (Silver Spring), 21(Suppl 1), S1–S27. https://doi.org/10.1002/oby.20461– Comparisons of outcomes between pharmacologic and surgical weight loss interventions.
FDA Approval Documents:
- Ozempic (semaglutide) approved in 2017 for type 2 diabetes
- Wegovy (semaglutide for weight loss) approved in 2021
- Mounjaro (tirzepatide) approved in 2022 www.fda.gov