Concussion, head injuries and Hyperbaric Oxygen Therapy

What is HBOT?

Hyperbaric Oxygen Therapy (HBOT) involves breathing 100% oxygen within a pressurised chamber, which enhances oxygen absorption into the bloodstream due to the increased pressure. Traditionally used for conditions like decompression sickness, HBOT is now gaining popularity for treating a variety of other conditions, including traumatic brain injuries (TBI).

Understanding Traumatic Brain Injury (TBI)

Traumatic Brain Injury (TBI) happens when a blow, bump, or jolt to the head disrupts normal brain function. The severity of TBI can vary from mild concussions to severe injuries involving extended periods of unconsciousness or amnesia. While most concussions resolve with rest and proper care, some can result in long-term issues such as chronic headaches, cognitive difficulties, and emotional changes. Severe brain injuries can lead to long-term complications like memory loss, lack of focus, and even paralysis.

How Does HBOT Help with Concussions and Brain Injuries?

After a TBI, the brain requires extra energy to heal. HBOT can enhance oxygen levels in the blood and tissues, providing the necessary oxygen for efficient energy production through aerobic metabolism, crucial for brain repair. Elevated oxygen levels from HBOT can help by:

  • Increasing Blood Flow: HBOT promotes better blood circulation to damaged brain areas, aiding in faster recovery.
  • Enhancing Metabolism: By increasing oxygen availability, HBOT supports the brain’s metabolic needs during the healing process.
  • Promoting Neuroplasticity: HBOT has been shown to help form new blood vessels in the brain and improve both white and grey brain matter, suggesting it can regenerate nerve fibres.
  • Stimulating Angiogenesis: The growth of new blood vessels supports rehabilitation and functional improvement. Evidence from human trials has shown significant improvements in patients with TBI, even years after the initial injury.
  • Supporting Brain Recovery: HBOT encourages cell growth, enhances resistance to oxidative stress, and potentially alters gene expression to aid in healing.
  • Reducing Inflammation: Brain injuries often cause inflammation, which can lead to severe brain damage. HBOT can help decrease inflammation and has been shown to improve neurological function in animal studies.

Benefits of HBOT for TBI

Many studies have demonstrated significant improvements in quality of life, cognitive function, memory, depression, and anxiety for TBI patients undergoing HBOT. Clinical improvements have been correlated with better activity in relevant brain areas as seen in CT scans.

A significant study looked at how hyperbaric oxygen therapy (HBOT) helps nerve fibres regrow in people with traumatic brain injury (TBI) who have post-concussion syndrome. Using a special type of MRI called diffusion tensor imaging (DTI), researchers saw big improvements in symptoms and found signs of healing in different parts of the brain. This means the nerve fibres are recovering, which is a hopeful sign of recovery.

Optimal Timing for HBOT

Studies suggest that HBOT can yield benefits anywhere from 6 months to 33 years post-injury, although earlier treatment is logically more beneficial. One analysis even recommends incorporating HBOT into the standard intensive care regimen for TBI due to evidence showing higher neurological function and better recovery with lower mortality rates in HBOT-treated patients.

Conclusion

HBOT offers a promising, non-invasive treatment option for individuals suffering from concussions and traumatic brain injuries. By enhancing oxygen supply, promoting neuroplasticity, stimulating angiogenesis, and reducing inflammation, HBOT can significantly aid in the recovery process, improving both cognitive function and quality of life for TBI patients. As research continues to support its efficacy, HBOT may become an integral part of the multidisciplinary management of traumatic brain injuries.

Click here to learn more about Hyperbaric Oxygen Therapy and book an appointment.

References

Boussi-Gross, R., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Bergan, J., Friedman, M., Hoofien, D., Shlamkovitch, N. & Ben-Jacob, E. 2013, “Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury-randomized prospective trial”, PloS one, vol. 8, no. 11, pp. e79995.

Golden, Z.L., Neubauer, R., Golden, C.J., Greene, L., Marsh, J. & Mleko, A. 2002, “Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen therapy”, International Journal of Neuroscience, vol. 112, no. 2, pp. 119-131.

Hadanny, A., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Suzin, G., Ben-Jacob, E. & Efrati, S. 2015, “Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage”, Restorative Neurology and Neuroscience, vol. 33, no. 4, pp. 471-486.

Hadanny, A., Abbott, S., Suzin, G., Bechor, Y. & Efrati, S. 2018, “Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis”, BMJ open, vol. 8, no. 9, pp. e023387.

Harch, P.G., Andrews, S.R., Fogarty, E.F., Amen, D., Pezzullo, J.C., Lucarini, J., Aubrey, C., Taylor, D.V., Staab, P.K. & Van Meter, K.W. 2012, “A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder”, Journal of neurotrauma, vol. 29, no. 1, pp. 168-185.

Ortega, M.A., Fraile-Martinez, O., García-Montero, C., Callejón-Peláez, E., Sáez, M.A., Álvarez-Mon, M.A., García-Honduvilla, N., Monserrat, J., Álvarez-Mon, M. & Bujan, J. 2021, “A general overview on the hyperbaric oxygen therapy: applications, mechanisms and translational opportunities”, Medicina, vol. 57, no. 9, pp. 864.

Tal, S., Hadanny, A., Berkovitz, N., Sasson, E., Ben-Jacob, E. & Efrati, S. 2015, “Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury”, Restorative Neurology and Neuroscience, vol. 33, no. 6, pp. 943-951.

Tal, S., Hadanny, A., Sasson, E., Suzin, G. & Efrati, S. 2017, “Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients”, Frontiers in human neuroscience, vol. 11, pp. 508.

Tsutsumi, Y., Tsutsumi, I., Tsujimoto, Y., Takahashi, S., Tsuchiya, A., Miyakoshi, C., Fukuma, S. & Furukawa, T.A. 2017, “Hyperbaric oxygen therapy for persistent postconcussion syndrome following mild traumatic brain injury”, The Cochrane Database of Systematic Reviews, vol. 2017, no. 7.

Wang, F., Wang, Y., Sun, T. & Yu, H. 2016, “Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis”, Neurological Sciences, vol. 37, pp. 693-701.