PRP vs Traditional Hair Loss Treatments: Where the U225 Meso Gun Fits In

Recognising What Traditional Therapies Offer

Understanding how newer modalities compare requires a grounded look at the established pillars of hair-loss therapy. Among them, topical minoxidil remains one of the most recognised first-line treatments.

• Widely available in 2% and 5% formulations, minoxidil has repeatedly demonstrated efficacy in slowing shedding and increasing hair density [10]. Yet it demands consistent, long-term commitment: twice-daily application for months, often indefinitely, is required to sustain results. Many patients discontinue use prematurely, not because the treatment fails but because the routine becomes impractical or because side effects such as irritation reduce compliance [11].
• Oral finasteride is another cornerstone, particularly for men. Acting by reducing dihydrotestosterone – the hormone intimately involved in follicular shrinkage – finasteride has been shown in multiple trials and meta-analyses to be one of the most effective non-surgical therapies available [12][13]. However, because it exerts systemic hormonal effects, it is not suitable for everyone, especially women of childbearing potential [1]. Some patients, concerned about potential sexual or mood-related side effects, prefer to avoid oral medications altogether.
• Low-level laser therapy offers a non-invasive alternative. With the rise of home-use laser helmets and devices, patients can stimulate the scalp using specific wavelengths of red or near-infrared light believed to enhance cellular metabolism and follicular activity. While studies indicate meaningful benefit for many users, [15] the results remain dependent on consistent use – often three or more times per week for several months – making adherence another limiting factor.
• Among the regenerative therapies, PRP has become one of the most sought-after. The process involves drawing a patient’s own blood, separating the platelet-rich component, and injecting it into the scalp to stimulate healing pathways and follicular activity [16]. A systematic review of PRP studies found that more than 80% reported positive effects on hair growth, particularly in density and thickness [17].

Researchers have also noted that combining PRP with existing treatments, such as minoxidil or finasteride, can increase overall effectiveness [18]. And importantly, PRP’s safety profile is strong, with adverse effects usually mild and temporary [19].

Yet despite its popularity, PRP lacks universal standardisation. Studies differ widely in platelet concentration, injection depth, injection volume, and treatment frequency. For example, two patients receiving ‘PRP’ may actually be undergoing significantly different procedures. This variability shows why improvements in technique – and in the devices used – are becoming increasingly important.

Moving to Mesotherapy and the Promise of Localised Delivery

Within the broader sphere of injectable solutions, mesotherapy has gained traction as a way to deliver bioactive compounds directly into the middle layer of the skin, the mesoderm, which sits close to the hair follicles.

Rather than relying on systemic absorption or surface-level penetration, mesotherapy introduces growth factors, peptides, vitamins, and sometimes microdosed pharmaceuticals precisely where they can impact follicular health [20].

Mesotherapy brings several advantages. It allows clinicians to tailor the formulation to the individual: a patient in early-stage thinning may benefit from a regenerative mixture, while a patient with diffuse shedding might require additional cocktail components designed to support cellular metabolism [20][21].

Because the injections are localised, systemic exposure is minimal – an important consideration for those wary of oral medications. Mesotherapy can also be combined with PRP, enabling a layered regenerative and nutritive approach that harnesses the patient’s own biology alongside targeted compounds [22].

The challenge, historically, has been consistency. Manual mesotherapy requires a clinician to make dozens – sometimes hundreds – of tiny injections in a session. Even in expert hands, manual technique introduces normal fluctuations in depth, angle, and dose, which influence treatment uniformity and patient comfort.

This is where technological refinements have reshaped the field.

Considering the U225 Meso Gun in Hair Loss Treatment

At The Health Suite Leicester, the integration of the U225 meso gun reflects a commitment to elevating hair-loss treatment through precision and patient experience.

Unlike manual mesotherapy, the U225 gun uses pneumatic pressure to deliver extremely rapid micro-injections at controlled depths and volumes [23]. This level of calibration ensures that every area of the scalp receives a consistent dose – something difficult to achieve manually, especially across larger treatment zones.

The gun’s high-frequency, low-force mechanism reduces discomfort and minimises tissue trauma, leading to less redness, less bruising, and practically no downtime. Treatments can be performed efficiently while maintaining meticulous technique, making the therapy more accessible for individuals with busy schedules [23].

Crucially, the U225 gun is not merely a ‘device’ but a platform. It enables The Health Suite’s clinicians to deliver a range of advanced formulations – from PRP to growth-factor blends to targeted mesotherapy cocktails – with enhanced accuracy. The technology does not replace clinical judgment; instead, it amplifies it, ensuring that each therapeutic ingredient reaches the intended depth with minimal variation.

Patients experiencing early to moderate stages of androgenetic alopecia often respond particularly well to U225-delivered mesotherapy or PRP [24]. At this point, follicles are weakened but still viable, and targeted regenerative stimulation can meaningfully improve density, thickness, and shedding patterns. Those who are hesitant to take oral finasteride because of side-effect concerns often find mesotherapy an appealing alternative or complement.

The approach is also ideally suited for patients already using minoxidil or laser therapy and wanting to enhance their regimen. Because mesotherapy works through a different mechanism – localised bio-stimulation – it fits naturally into multi-modal treatment plans.

In addition, many patients choose the U225 mesotherapy approach as a long-term maintenance strategy. Once initial improvements stabilise, periodic sessions can help sustain follicular health without the commitment of daily medication or device use.

Understanding Safety and the Importance of Protocol-Driven Care

While the U225 meso gun itself is a delivery mechanism rather than a biological treatment, the scientific basis for the therapies it administers is robust. PRP continues to show promising results in both clinical trials and real-world settings, with strong safety data and a biologically plausible mechanism involving growth-factor-driven follicular activation.

Studies examining combination therapies – particularly PRP paired with minoxidil – consistently show improvements greater than those seen with monotherapies alone [25]. Growth-factor-based mesotherapy has also shown favourable results in emerging research, though further high-quality trials are required to standardise formulations and protocols [20].

What matters most in clinical practice is consistency.

The variability that sometimes affects PRP and mesotherapy outcomes comes not from the underlying science but from differences in how treatments are prepared and administered. A protocol-driven approach, combined with the U225’s precise delivery, helps reduce that variability.