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Below are the key blood tests used in Rheumatology, each focusing on a specific hormone or indicator.
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Albumin is a protein produced by the liver that helps maintain blood volume and transport nutrients. In rheumatology blood tests, measuring albumin helps assess inflammation, nutritional status, and overall liver and systemic health.
Anti-CCP (Anti-Cyclic Citrullinated Peptide) antibodies are specific markers for rheumatoid arthritis. Testing helps diagnose RA early, assess disease activity, and guide treatment to manage joint inflammation and prevent long-term damage.
Anti-Jo-1 (Anti-histidyl-tRNA synthetase antibody) is an autoantibody associated with autoimmune conditions like polymyositis and interstitial lung disease. Testing helps diagnose these disorders, assess disease activity, and guide treatment planning.
Anti-La (SS-B) antibodies are autoantibodies associated with Sjögren’s syndrome and sometimes lupus. Testing helps diagnose autoimmune conditions, assess disease activity, and guide management of symptoms such as dry eyes, dry mouth, and systemic involvement.
Anti-Ro (SS-A) antibodies are autoantibodies linked to Sjögren’s syndrome and systemic lupus erythematosus. Testing helps diagnose autoimmune conditions, assess disease activity, and guide management of symptoms like dry eyes, dry mouth, and systemic complications.
Anti-Smith (Anti-Sm) antibodies are specific autoantibodies associated with systemic lupus erythematosus (SLE). Testing helps confirm a lupus diagnosis, assess disease activity, and guide management of autoimmune and systemic symptoms.
Anti-Smith (Anti-Sm) antibodies are specific autoantibodies associated with systemic lupus erythematosus (SLE). Testing helps confirm a lupus diagnosis, assess disease activity, and guide management of autoimmune and systemic symptoms.
Antibodies to Extractable Nuclear Antigens (ENA) are autoantibodies associated with autoimmune disorders like lupus, Sjögren’s syndrome, and mixed connective tissue disease. Testing ENA helps diagnose specific autoimmune conditions, assess disease activity, and guide treatment.
C-Reactive Protein (CRP) is a marker of inflammation in the body. Measuring CRP levels helps detect acute or chronic inflammation, monitor autoimmune or infectious conditions, and guide treatment decisions in rheumatology and overall health management.
CENP-B (Anti-Centromere Protein B) antibodies are autoantibodies associated with limited systemic sclerosis (scleroderma). Testing helps diagnose this autoimmune condition, assess disease activity, and guide management of symptoms like skin thickening and vascular involvement.
A Full Blood Count (FBC) measures red and white blood cells, haemoglobin, and platelets. It provides a comprehensive overview of blood health, helping detect anaemia, infections, clotting issues, and monitor overall metabolic, immune, and systemic health.
Extractable Nuclear Antigens (ENA) are a group of autoantibodies associated with autoimmune diseases such as lupus, Sjögren’s syndrome, and mixed connective tissue disease. Testing ENA helps diagnose specific autoimmune conditions, assess disease activity, and guide treatment.
Rheumatoid Factor (RF) is an autoantibody often present in rheumatoid arthritis and other autoimmune conditions. Testing RF helps diagnose RA, assess disease activity, and guide treatment to manage joint inflammation and prevent long-term damage.
Serum Crosslaps (DPD) measures C-terminal telopeptides of type I collagen, indicating bone resorption levels. Testing helps assess bone turnover, monitor osteoporosis or metabolic bone disease, and guide treatment for maintaining bone health.
Uric acid is a waste product from purine metabolism. Measuring uric acid levels helps assess the risk of gout, kidney stones, and metabolic disorders, and supports monitoring of overall kidney, cardiovascular, and metabolic health.
Alkaline Phosphatase (ALP) is an enzyme found in the liver, bones, and other tissues. Measuring ALP helps assess liver and bone health, detect liver disease or bone disorders, and monitor overall metabolic and skeletal function.
Anti-CENP (Anti-Centromere Protein) antibodies are autoantibodies associated with limited systemic sclerosis (scleroderma). Testing helps diagnose this autoimmune condition, assess disease activity, and guide management of symptoms like skin thickening and vascular complications.
Anti-La (SS-B) antibodies are autoantibodies associated with Sjögren’s syndrome and sometimes systemic lupus erythematosus. Testing helps diagnose autoimmune conditions, assess disease activity, and guide management of symptoms such as dry eyes, dry mouth, and systemic involvement.
Anti-nRNP (Anti-Nuclear Ribonucleoprotein) antibodies are autoantibodies associated with mixed connective tissue disease and other autoimmune conditions. Testing helps diagnose specific autoimmune disorders, assess disease activity, and guide management of systemic symptoms.
Anti-nRNP (Anti-Nuclear Ribonucleoprotein) antibodies are autoantibodies associated with mixed connective tissue disease and other autoimmune conditions. Testing helps diagnose specific autoimmune disorders, assess disease activity, and guide management of systemic symptoms.
Anti-AChR (Acetylcholine Receptor) antibodies target receptors at the neuromuscular junction. Testing helps diagnose myasthenia gravis, assess disease severity, and guide treatment for muscle weakness and related autoimmune neuromuscular conditions.
Anti-dsDNA IgG antibodies target double-stranded DNA and are highly specific for systemic lupus erythematosus (SLE). Testing helps diagnose lupus, monitor disease activity, and guide treatment to manage autoimmune and systemic symptoms.
Antinuclear Autoantibodies (ANA) are autoantibodies that target the nuclei of cells. Testing for ANA helps detect autoimmune disorders such as lupus, Sjögren’s syndrome, and scleroderma, assess disease activity, and guide diagnosis and management of systemic autoimmune conditions.
Calcium is a vital mineral in the blood essential for bone health, muscle function, and nerve signaling. Measuring calcium levels helps assess bone metabolism, parathyroid and kidney function, and overall metabolic and cardiovascular health.
Erythrocyte Sedimentation Rate (ESR) measures how quickly red blood cells settle in a test tube over an hour. A faster rate indicates inflammation, infection, or chronic disease, helping monitor autoimmune conditions, systemic inflammation, and overall health.
HLA-B27 is a genetic marker associated with autoimmune conditions such as ankylosing spondylitis and reactive arthritis. Testing helps assess susceptibility, support the diagnosis of autoimmune or inflammatory disorders, and guide disease management.
Phosphate is a mineral essential for bone health, energy production, and cellular function. Measuring phosphate levels helps assess bone metabolism, kidney function, and overall metabolic and electrolyte balance.
Salivary Antibodies (SAB) are antibodies detected in saliva that reflect an immune response to infections or allergens. Testing SAB helps assess oral and systemic immunity, monitor exposure to pathogens, and support overall immune and health evaluation.
Striated Muscle Antibodies (Anti-Skeletal Muscle Antibody, ASKA) are autoantibodies targeting skeletal muscle tissue. Testing helps diagnose autoimmune muscle disorders, such as myasthenia gravis, assess disease activity, and guide treatment of neuromuscular conditions.
Vitamin D (25‑OH) measures the main circulating form of vitamin D in the blood. It helps assess bone health, immune function, and hormonal balance, guiding supplementation and overall metabolic and wellness management.
Browse and click below to book any of our available Rheumatology Blood Tests at The Health Suite Leicester.
Rheumatology Disease Blood Test
Included in the Rheumatology Disease Blood Test
* Full Blood Count (FBC)
* Erythrocyte Sedimentation Rate (ESR)
* Uric Acid
* Rheumatoid Factor
* Anti-CCP (Anti-Cyclic Citrullinated Peptide) Antibodies
* C Reactive Protein
Connective Tissue Disease Blood Test
Included in the Connective Tissue Disease Blood Test
* Full blood count (FBC)
* Erythrocyte sedimentation rate (ESR)
* Uric Acid
* Antinuclear Autoantibodies
* Anti-dsDNA (Anti-double-stranded DNA) IgG
* Antibodies to Extractable
* Nuclear Antigens (ENA)
* Anti nRNP (Anti-Nuclear Ribonucleoprotein)
* Anti Sm (Anti-Smith antibody)
* Anti Ro (SS-A) (Anti-Sjögren’s syndrome A (Ro) antibodies)
* Anti La (SS-B) (Anti-Sjögren’s syndrome type B (SS-B) antibody test)
* Anti Jo-1 (Anti-histidyl-tRNA synthetase antibody)
* Anti Scl 70 (Anti-topoisomerase I antibody)
* Anti CENP (Anti-Centromere Protein)
* Rheumatoid Factor (RF)
* Anti CCP (Anti-cyclic citrullinated peptide) Antibodies
* C Reactive Protein
* CENP-B (Anti-Centromere Protein B Antibodies)
Myasthenia Gravis Blood Test
Included in the Myasthenia Gravis Blood Test
* Anti-AChR Ab (Acetylcholine Receptor (AChR) Antibody)
* Striated Muscle Ab (Anti-Skeletal (Striated) Muscle Antibody (ASKA))
Sjogrens Disease Blood Test
Included in the Sjogrens Disease Blood Test
* Anti RO (SS-A) (Anti-Sjögren’s Syndrome A (Ro) autoantibodies)
* Anti La (SS-B)
* Salivary Antibodies (SAB)
* C Reactive Protein
Osteoporosis Blood Test
Included in the Osteoporosis Blood Test
* Alkaline Phosphatase
* Calcium
* Albumin
* Phosphate
* Serum Crosslaps (DPD)
* Vitamin D (25 OH)
HLA B27 Blood Test
Included in the HLA B27 Blood Test
* HLA B27 Gene (Human Leukocyte Antigen)
Blood Test Results Discussion with GP (Telephone)
Included in the Blood Test Results Discussion with GP (Telephone)
Discuss your blood test results with a GP via telephone. Convenient, confidential consultation to review findings, explain results, and advise on next steps or treatment if needed.
Common Q&A about Rheumatology Blood Tests
Our FAQ section is designed to address common questions you may have, from how our treatments work to what you can expect during and after your session.
Our team is always available to provide additional support if you need more personalised guidance, ensuring that you feel informed and confident every step of the way.
Rheumatology Blood Tests are specialized tests used to detect and monitor autoimmune and inflammatory conditions that affect the joints, muscles, and connective tissues, such as rheumatoid arthritis, lupus, and ankylosing spondylitis.
These tests are crucial for diagnosing rheumatic diseases early, which allows for timely treatment and management. Early detection can help prevent joint damage, organ involvement, and other serious complications associated with these conditions.
Common tests include the Rheumatoid Factor (RF), Anti-Cyclic Citrullinated Peptide (Anti-CCP), Antinuclear Antibody (ANA), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and HLA-B27.
Tests like Rheumatoid Factor (RF) and Anti-CCP are used to detect antibodies that are often present in rheumatoid arthritis. Elevated levels of these antibodies, along with symptoms, can help confirm a diagnosis.
The ANA test detects autoantibodies that target the cell nuclei, which are often present in autoimmune diseases like lupus. A positive ANA test can indicate the presence of an autoimmune disorder, but further tests are usually needed for a definitive diagnosis.
Yes, tests like ESR and CRP measure the level of inflammation in the body and are used to assess disease activity. High levels may indicate an active inflammatory process, which can help guide treatment decisions.
Generally, no special preparations are needed for most rheumatology blood tests. However, your doctor may provide specific instructions based on the tests being performed, such as fasting or avoiding certain medications.
These tests can help diagnose a range of rheumatic conditions, including rheumatoid arthritis, lupus, Sjogren’s syndrome, scleroderma, polymyalgia rheumatica, and ankylosing spondylitis.
Results typically take a few days to a week, depending on the specific tests performed and the laboratory processing them. Your healthcare provider will discuss the results with you and determine the next steps.
While these tests provide critical information, they are usually part of a comprehensive diagnostic process that includes a physical exam, medical history, and imaging studies. Positive or abnormal results often require further testing and evaluation to confirm a diagnosis.
