Just Blue

Strength
16mg. dividable into quarters or halves.

Delivery mechanism
The Buccal Troche: a small lozenge that dissolves between the upper cheek and gums. In contrast to a tablet or capsule, the ingredients are directly absorbed into the cheek mucosa for a more reliable and rapid onset of action, typically between 15 and 20 minutes.

Troches are scored for easy titration.

Just Blue can also be swallowed due to high bioavailability. If swallowed, it is best taken on an empty stomach for optimal absorption.

Dosing
Start with 1/4 to 1/2 troche and titrate the dose every 3 to 5 days until symptom improvement. If not achieved by 16mg, consider Tro+ Blue dosing. After symptom improvement, consider daily dosing for 2 to 4 weeks with sequent titration down, depending on needs.

Mechanismofaction

• Mitochondria:
  • Increases ATP production (donates electrons to complex IV on ETC)
  • Increases antioxidant reserve (accepts electrons to neutralize ROS)
  • Increases NAD+ production via enhanced glycolysis and NADPH oxidation
• Mild MAOI ➔ Increases serotonin, dopamine, and norepinephrine
• Benefits include enhanced:
  • Energy
  • Neuroprotection
  • Endurance
  • Mood Boosting

Interactions
SSRI and SNRI medications (at our dosing, any interaction would be rare and many clinicians are using our MB with these drugs under very close supervision). Full list are linked below (per ingredient)

Contraindications

• Pregnant or breastfeeding
• Hepatic or renal impairment
• Any known sensitivity to methylene blue or thiazine dyes

Possible side effects

• Blue urine: Methylene Blue concentrates in the urine. This is a benign side effect.
• Blue tongue/teeth: Also benign, lasts 4 to 6 hours. Here are some remedies to help it go away faster if needed. Do NOT use if plastic veneers are in place. ConsuIt a dentist for any concerns.
• Some users report mild headaches. When it does occur, it is usually mild and resolves after the first few doses. If this occurs, we suggest starting with 1/4 or even 1/8 troche and slowly titrating up.
• Numbness/tingling of tongue or cheek: due to peppermint in the formula. If it occurs, troches can be swallowed on an empty stomach with the same benefits.
• Higher doses of MB (>1 mg/kg)–much higher than in our formula–can lead to GI biofilm disruption, oxidative stress, and gastric ulceration. See this article for more information.

Inactive ingredients
Polyethylene Glycol (PEG), stevia extract, luo han extract, peppermint, silica, Bitter-Bloc.