Polynucleotide Treatment in Leicester

The published evidence is stronger for wound healing and for laboratory measures of fibroblast activity than it is for aesthetic outcomes. Studies of skin quality are small and short, and few compare polynucleotides directly against hyaluronic acid skin boosters. In practice, most patients completing a full course see an improvement in hydration and texture, but the change is moderate and gradual. If you are expecting a lift or a change in facial contour, this is the wrong treatment.

There is no immediate result. Improvement in hydration is often noticed within the first two to three weeks. Changes in texture and elasticity develop across the course and for several weeks after the third treatment, so the fullest effect is usually apparent around six to eight weeks after completing the course.

Longevity varies with age, skin condition, sun exposure and individual response, and there is little long-term published data. Maintenance is generally considered at around six months. That interval is a pragmatic clinical convention rather than a figure derived from trial evidence.

Polynucleotides have an established record in medical use and Plinest is regulated in the UK as a medical device. Side effects are usually limited to redness, swelling, tenderness and small bumps at the injection points. Less common problems include prolonged swelling, palpable nodules and injection-site infection. Allergic reaction is uncommon but possible given the fish origin of the product. As with any facial injectable, vascular occlusion is a rare but recognised risk, which is why treatment should be carried out by a practitioner trained to recognise and manage complications.

Discomfort is mild for most patients. The injections are fine and superficial. Topical anaesthetic can be applied beforehand. The under-eye area is generally the most sensitive.

Small raised areas at each injection point are expected immediately afterwards and usually settle within a few hours as the product disperses. Around the eyes they can occasionally persist into the following day.

No. Fillers add volume and provide structural support. Polynucleotides are intended to improve the condition of the skin and will not change facial shape or fill a hollow.

Three treatments approximately three weeks apart initially, then a single maintenance treatment at around six months. Treating more frequently is not known to improve results.

Often, yes, as part of a wider treatment plan. Sequencing and the interval left between procedures both matter, and your practitioner will advise on this at consultation.